Talbot Road, Dickson Road and Queen Street were closed by police at approximately 7pm today (December 20).
Emergency services were called to the scene and motorists and pedestrians were urged to avoid the area.
"Please avoid the area and make alternative travel arrangements where possible," a spokesman for Lancashire Police said.
The Force Incident Manager for Lancashire Police said he believed the incident was a road traffic collision, but he was unable to provide any more details at the time he was contacted.
There were unconfirmed reports the collision involved a pedestrian and a vehicle.
Lancashire Police were approached for more information.
Thanks for reading. If you value what we do and are able to support us, a digital subscription is just £1 for your first month. Try us today by clicking HERE.