Major roadworks are set to start to build a new link road through Poulton.
The construction is being carried out to reduce traffic congestion and air quality through the town, starting from Monday.
But engineers have warned it is set to cause disruptions to traffic flow for around 16 weeks.
Lancashire County Council is undertaking the work to build a new road through Hardhorn Road car park, running between The Elk pub on Hardhorn Road and Poulton Bridge Club on Blackpool Old Road.
Road improvements will also be carried out and additional pedestrian crossings will be put in place.
Neil Stevens, highways development control manager for the authority, said: “The link road will contribute to improving traffic flow through Poulton and help to deal with the extra traffic which will be generated by the new Booths development.
“There will be some disruption as a result of the road closures and diversions that are needed while we carry out this work, but we’ll be doing our best to keep this to a minimum.”
Hardhorn Road car park will be closed for six weeks from Monday, due to be reopened from August 1.
Alternative parking will be available at Teanlowe and Booths car parks, each accessible from Ball Street.
Closures of parts of Blackpool Old Road, Hardhorn Road and Queens Square will also be required at various times however engineers have said these will be staggered and diversions for both vehicles and pedestrians will be signposted.
The new road will allow northbound traffic to turn left from Hardhorn Road and travel on to Blackpool Old Road and Queensway.
The work is aimed at reducing traffic congestion around the town centre and improving air quality on Chapel Street, which is subject to a dedicated programme to tackle pollution.
It will also improve access to Teanlowe car park, the new Booths store which is due to open in November and businesses in and close to the town centre, County Hall says.
Drivers are being advised to seek out other routes during the work.
Mr Stevens added: “I’d ask people to consider taking alternative routes if they can, or leave more time for their journey.”