Passengers are being advised to avoid the West Coast main line and to check before they travel over the Christmas period due to track works.
Network Rail warned the route will be closed between London Euston and Hemel Hempstead after the last trains tonight until Monday, December 29.
It will also be closed between Stafford and Crewe after the last trains on Christmas Eve until Sunday December 28.
It said the closures are so work can be carried out to introduce new signalling and to provide faster services and capacity for more trains.
Journeys made on the West Coast main line in and out of London and between the West Midlands and north west of England will be longer and are likely to involve a bus replacement service.