Passengers travelling to and from Blackpool North train station on Wednesday will have to rely solely on buses.
Northern has announced the full timetable for train services set to run during the RMT strike.
The hourly train to Preston will not run but there will be a bus every 15 minutes until 7pm.
Commuters have already been using the buses for months while the line shut for electrification work. Since it re-opened, a reduced service has been in operation to allow for driver training, with the buses being kept on.
Sharon Keith, regional director for Northern, said: “Being able to run so many services, supplemented by the extra rail replacement buses, means we will be able to keep the north of England on the move.
“Our amended timetables have been developed to provide the best possible cover, with a particular focus on providing services at the busiest times on our busiest routes.
“Despite this planning, we expect all services to be busy and ask our customers to plan ahead accordingly.”
Full details of the revised timetables – together with rail replacement bus schedules – and supporting information for customers can be found at www.northernrailway.co.uk/strike.