They will do so without as many as 10 players, with nine out injured and Gary Madine serving the second match of his four-game suspension.
There is better news regarding Curtis Nelson though, with the defender returning to training after missing the weekend draw with Rotherham with a groin strain.
With that in mind, here’s how we think the Seasiders might line up against Russell Martin’s side...
1. On the hunt for a big win
The Seasiders can move out of the bottom three with a win against the Swans Photo: CameraSport - Dave Howarth
2. GK - Chris Maxwell
The skipper will have to be at his best once again after making some crucial saves in recent games. Photo: CameraSport - Dave Howarth
3. RB - Andy Lyons
The Irishman has made an impressive start to his Blackpool career. Photo: CameraSport - Dave Howarth
4. CB - Callum Connolly
The former Ipswich man has done well filling in at centre-back and is a player McCarthy trusts. Photo: CameraSport - Dave Howarth
5. CB - Curtis Nelson
This is the big call for McCarthy. Does he stick with Jordan Thorniley, who was excellent on his return to the side, or bring Nelson straight back in now he's recovered from his groin strain? Photo: CameraSport - Dave Howarth
6. LB - James Husband
When you're in a real battle like Blackpool are they need players they can rely on, and Hubby is certainly one of them. Photo: CameraSport - Dave Howarth