LINE UPS: Potts misses out for Pool
The winger suffered the injury towards the end of Blackpool's 0-0 draw at Cambridge at the weekend, which forced him off the field.
He's replaced by skipper Danny Pugh who comes into a midfield three as Gary Bowyer keeps faith with the 3-5-2 formation.
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Hide AdTom Aldred keeps his place in the team after his red card against Cambridge was overturned following a successful appeal by the club.
The Tykes, who drew 0-0 with the Seasiders in the original tie at Bloomfield Road, come into the game on the back of a 2-0 defeat at Fulham at the weekend.
Barnsley: Davies, Bree, White, Roberts, MacDonald, Scowen, Hammill, Hourihane, Kent, Armstrong, Bradshaw
Subs: Townsend, Evans, Jackson, Moncur, Watkins, Williams, Payne
Blackpool: Slocombe, Mellor, Aimson, Aldred, Robertson, Taylor, Pugh, McAlister, Payne, Vassell, Cullen
Subs: Lyness, des Pres, Philliskirk, Osayi-Samuel, Yeates, Matt, Gnanduillet
Referee: Roger East