The M6 southbound between junctions 33 and 32 is currently closed following a two vehicle collision and is expected to remain closed for at least an hour.
Drivers are asked to avoid the area where possible.
Police were called around 9.10am following a collision between a Toyota and a Volkswagen Polo.
The two drivers, a man and a woman, have been taken to Royal Preston Hospital.
One was airlifted to hospital, but the full extent of their injuries is as yet unknown.