A 24-year-old suffered serious injuries when his Jeep Cherokee clipped a traffic island, flipped over, hit two parked cars, and come to a stop on a Layton pavement.
Emergency services were called to the smash, which happened near to the junction of Westcliffe Drive and Highbury Avenue, at around 1.55am today.
Firefighters from Blackpool used hydraulic cutting equipment to free the Poulton man from his vehicle, before strapping him to a long board and handing him over to paramedics.
He was taken to Royal Preston Hospital with serious head injuries, although he was conscious and breathing, a spokeswoman for the North West Ambulance Service said.
Westcliffe Drive was closed from The Layton (Institute) to Tesco Express until around 9.30am while debris was cleared and police officers carried out an accident investigation.
Buses were affected, with number nine, 11, and 14 services all diverted, Blackpool Transport said, although normal service has now resumed.
The two parked cars damaged were a Ford Fiesta, which was hit first, and a Citroen Xsara Picasso, a spokeswoman for Lancashire Police said.
Sgt John Jennings-Wharton, of the Road Policing Unit, added: "I am particularly keen to hear from anyone who may have seen the Jeep driving prior to the collision.
"If anyone has any information that could assist with our enquiries, I would urge them to contact us."
Information can be reported by calling police on 101, quoting log number 72 of May 12.