Fylde had an uphill struggle on their hands as they trailed at the interval in this National League One clash at the Woodlands.
Fylde took the lead with an outstanding individual try by Anthony Bingham, goaled by Greg Smith after only three minutes.
Cambridge retaliated with a tries by Oliver Petriades and Stefanes Liebenberg, with Daniel Lewis adding a penalty and a conversion.
Jack Turley hit back with a Fylde try goaled by Smith, but Cambridge increased their advantage with a converted Mike Ayrton try.
Deep into first half stoppage time, Mike and James Ayrton rubbed home Cambridge's advantage with two more tries, both converted.