Resurfacing work, drainage repairs and lighting installation is being carried out around Junction 1 (Broughton) of the M55.
This will affect both the eastbound and westbound M55 links to and from the southbound M6.
All the work will be taking place between 8pm and 6am each night with lane closures in place.
The Highways Agency is warning drivers that full closures of the motorway carriageways will also be necessary, which will be publicised on the motorway.
Diversions will be in place when the road is closed, and the project is due to be completed by Sunday, December 22.